In addition to its structural role, the skeleton has also been recognized as an endocrine organ for the hormonal modulation of energy homeostasis. Bone-derived secretory factors comprise an important endocrine system that is finely orchestrated with other organs to ensure homeostatic balance and health.
How Bones help in endocrine regulation?
When applied to skeletal biology the concept of feedback regulation suggests that bone cells may exert an endocrine function. Bone remodeling, the process whereby bones renew themselves, is regulated by multiple hormones.
Do bone cells secrete hormones?
Indeed, bone cells are secreting at least two hormones, FGF23 and osteocalcin, which are implicated in the regulation of phosphate homeostasis and of energy metabolism, respectively.
Is bone an organ?
Bone is a mechanically optimized organ system whose composition and organization reflect the functional demands made upon it. Far from being an inert substance, it is also a living tissue that serves several important functions in the organism.
Do bones protect organs?
Bones provide support for our bodies and help form our shape. Although they’re very light, bones are strong enough to support our entire weight. Bones also protect the body’s organs. The skull protects the brain and forms the shape of the face.
Are bones a gland?
In addition, bone functions as an endocrine gland producing osteocalcin, which in turn interacts with other tissues, such as fat, pancreas and gastrointestinal tract. As a consequence, osteocalcin intervenes into glucose metabolism, peripheral insulin sensitivity and inflammatory process.
What is an endocrine organ?
An organ that makes hormones that are released directly into the blood and travel to tissues and organs all over the body. Endocrine glands help control many body functions, including growth and development, metabolism, and fertility. Some examples of endocrine glands are the pituitary, thyroid, and adrenal glands.
Are bone-forming cells?
Osteoblasts are bone-forming cells, osteocytes are mature bone cells and osteoclasts break down and reabsorb bone.
Are bones and muscles organs?
The human musculoskeletal system (also known as the human locomotor system, and previously the activity system) is an organ system that gives humans the ability to move using their muscular and skeletal systems.
Is Bone Marrow an organ?
In immunology and anatomy textbooks the bone marrow is described as a typical “primary lymphoid organ” producing lymphoid cells independent of antigens. The hematopoietic bone marrow is largely age-dependent organ with great anatomical and functional differences among various species.
Which bones protect organs?
Flat Bones Protect Internal Organs There are flat bones in the skull (occipital, parietal, frontal, nasal, lacrimal, and vomer), the thoracic cage (sternum and ribs), and the pelvis (ilium, ischium, and pubis). The function of flat bones is to protect internal organs such as the brain, heart, and pelvic organs.
Is a femur a bone?
Your thighbone (femur) is the longest and strongest bone in your body. Because the femur is so strong, it usually takes a lot of force to break it. Motor vehicle collisions, for example, are the number one cause of femur fractures. The long, straight part of the femur is called the femoral shaft.
What organs are protected by these bones?
Protects and supports organs: Your skull shields your brain, your ribs protect your heart and lungs, and your backbone protects your spine. Stores minerals: Bones hold your body’s supply of minerals like calcium and vitamin D.